Differential expression and translation of adenosine receptor agonists in human detrusor from stable and overactive bladders and its consequence in regulating detrusor contractility
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چکیده
Title: Differential expression and translation of adenosine receptor agonists in human detrusor from stable and overactive bladders and its consequence in regulating detrusor contractility.
منابع مشابه
Human idiopathic and neurogenic overactive bladders and the role of M2 muscarinic receptors in contraction.
OBJECTIVES This study examines whether M(2) receptors contribute to direct contraction of the detrusor in human neurogenic and idiopathic overactive bladders. METHODS Control detrusor muscle was obtained from patients undergoing cystectomy for bladder cancer, whilst overactive detrusor muscle was obtained from patients undergoing clam cystoplasty for idiopathic or neurogenic detrusor overacti...
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Two neurotransmitters, ACh and ATP, initiate nerve-mediated contractions in detrusor smooth muscle from guinea-pigs and humans with bladder over-activity; whereas only ACh has a role in muscle from stable human bladders. Both Acetylcholine and ATP are rapidly broken down, by acetylcholinesterases and ectonucleotidases respectively. The activity of ectonucleotidase has been shown to be reduced i...
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Background: In this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. Previous research showed a cytotoxic effect of adenosine via A3 receptor and A1 receptor and sometimes this effect was receptor independent. The researches showed a differential cytotoxic effect of adenosine and its A3 agonists on cancerous cells, while ot...
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The potential role of A1 adenosine receptors in modulating neuromuscular transmission in the detrusor muscle of the urinary bladder has been tested in human and murine preparations with the intent to determine the viability of using adenosine receptor agonists as adjuncts to treat overactive bladder. In human detrusor muscle preparations, contractile responses to electrical field stimulation we...
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